The study explores the impact of emotional stress on the efficacy of cancer immunotherapy, examining the relationship between emotional stress and the tumor immune microenvironment, and proposing a new model that combines biological-psychological factors (Psycho-biomarkers) to predict therapeutic outcomes. Additionally, it evaluates the potential of emotional stress interventions in enhancing immunotherapy efficacy and promotes the application of a multidisciplinary bio-psycho-social medical model in cancer clinical treatment.